MicroNeedling and the Transmission of Drugs

Many people today are scared of needles. Some people actually pass out at the sight of them. They are big and scary, and many of us remember getting shots as a child because they hurt. What if there was a way to receive a vaccine without a big, scary needle? What if we told you there is a way?

MicroNeedling is well-known as a non invasive cosmetic procedure that can be used to diminish the appearance of fine lines and wrinkles, as well as sagging skin, acne scars, stretch marks, and skin discolorations. But did you know microneedling is used for the transdermal delivery of drugs to the skin? MDPen, a professional microneedling company, will explore the history of microneedling and the transmission of drugs in the following blog post.


MicroNeedling in essence uses tiny needles to penetrate the skin to the lower layers. Hence, the idea and use of using microneedling to transmit drugs across the skin barrier has been around almost as long as modern microneedling, when the technology became available. This method is convenient, pain-free, and allows for a more controlled release of the drug into the patient. microneedling to deliver drugs is quite effective, especially for drugs that cannot cross the stratum corneum (the scientific name for the epidermis or outer layer of the skin) easily. Epinephrine is one example. Furthermore, by bypassing the blood stream, the drug is more effective as it bypasses hepatic metabolism and aludes GIT (gastrointestinal) degradation and can be delivered directly to the cytoplasm. This is especially useful for macromolecules.

Nanomedicine, the branch of medicine that uses nanotechnology, can be applied in treatment and diagnostics when dealing with nanoparticles or devices. Known as nanoformulation, this branch of medicine focuses on improving drug delivery and thus has been at the forefront of developing microneedling for the transmission of drugs.


  • Reduces side effects. Targeting areas naturally can eliminate side effects as well since the drug is only affecting targeted areas.
  • Pain-free delivery. Due to the small size of the needles, the nerve endings in the lower levels of the skin are not affected.
  • Improves therapeutic effect and reduces the toxicity levels. This method is great for cancer patients as the drugs can reach their target sites (tumor cells) without being lost to other organs or tissues.
  • Increases availability of drugs that can be used in treatments. Microneedles can be used to deliver a wide range of drugs, including insulin, amantadine, vitamin B, vaccines, and phenylephrine.
  • Improves the release of the drug. Because the drug is targeting a specific area and doctors know none of the medicine is being lost inside other areas of the body, doctors can control the exact dosage as well as the speed of delivery for optimal results.
  • Increase the treatment options. The advancement in microneedling technology and the needles available for use also increase the treatment options.
  • Intracellular delivery. microneedling can be used for the intracellular delivery of biomolecules like peptides, cell probes, genes, drugs, and proteins.
  • Ocular delivery. The eye is so small that microneedles are small enough to deliver ocular drugs locally or systemically in the eye cavity.
  • Happier patients. Shorter needles are less scary and may be easier to train patients to use at home if need be.
  • Convenient to use. Smaller needles are safer and easier to use and can deliver drugs in the particulate form. Due to these characteristics, they are convenient and more patient-compliant.
  • Minimally invasive. Hypodermic needles are more invasive and take longer to heal at the injection site.
  • Acts immediately. No more waiting 20 minutes for the effects of the drug to kick in. Relief and/or successful treatments are rapid.

The future possibilities are endless with microneedles and drug transmission. Scientists are hoping to use microneedling technology as electrochemical probes as well as optical sensors to be better able to study cells and their environments. The science of nanotechnology is beyond the scope of this article; however, the science remains the same: microneedling can be used to improve the transmission of drugs, which improves all of our lives.

With respect to dermatology, microneedling is already being combined with radiofrequency waves to increase patient results. It is in human nature to continually improve our lives. Our appearance is a very important part of who we are — both in our mind and in others. Hence, expect more non invasive cosmetic procedures to continue to emerge for perpetuity.


MDPen will be ready. As a leader in microneedling equipment, we’ve developed our own microneedling pens in order to deliver the best microneedling results for your skin. MDPen offers two microneedling pens for your convenience and preference: MDPen Dual Cordless/Electric Micro Needling and

. Both can adjust the penetration level of the needles and are easy to use. We offer microneedling training courses as well, so you can offer your patients the best option for their skin care needs.

MDPen set out to develop the best microneedling serums, and we think we’ve succeeded. Our Vegan formulations contain only organic ingredients that are paraben, petrochemical and SLS/SLE free, and are never tested on animals. We’ve developed a whole line that is perfect for after your microneedling procedure, or you can use our skin care line to replace your current skin care products. From moisturizers, cleansers, and serums, MDPen has got you covered for all your skin care needs. Visit us online today!

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