Think of peptides as tiny messengers for your skin cells. Their main job is to carry instructions, telling your skin to perform specific functions like building more collagen or repairing damaged tissue. On its own, your skin does this naturally. But after a microneedling treatment, your skin is primed and ready for these messages. The procedure creates thousands of micro-channels, allowing these peptides to penetrate deeper than they ever could on their own. This is why using peptides after microneedling is so effective. You’re giving your skin the precise tools and instructions it needs to rebuild itself stronger and healthier than before.

As a skin care ingredient, copper is priceless. Copper is showing up in more skin and hair products due to its effect in fighting signs of aging.
Copper peptides are naturally occurring complexes that have been used in personal care products since the 1990s. Investigation into the benefits of copper peptides began in 1973 by biochemist Loren Pickart. He discovered that liver cells could be revitalized by placing them in blood samples from younger people. When he isolated those plasma samples, he identified the substance as copper peptides.

In one of Harpar’s Bazar article, “Copper definitely plays an important role in maintaining healthy skin,” says dermatologist Joshua Zeichner, director of cosmetic and clinical research at Mount Sinai’s Department of Dermatology in New York.  “It helps to develop collagen and elastin, which maintain the strength of the skin, and it promotes the production of skin-plumping hyaluronic acid” (Translation: smoother and firmer).  “It also has antibacterial and anti-fungal properties, which help prevent infections,” he adds, which is why it has been used in wound care since the 60s (and shows high hopes for acne treatment too).

The Different Types of Peptides

When you see “peptides” on a skincare label, it’s helpful to know that they aren’t all created equal. Think of them as a team of specialists, where each type has a very specific job to do for your skin. Understanding their different roles can help you choose products that target your exact concerns, whether you’re focused on firming, smoothing, or overall repair. Let’s look at the three main players you’ll find in your serums and creams.

Signal Peptides

Signal peptides are the ultimate motivators for your skin cells. Their main job is to send messages that trigger the synthesis of collagen and elastin—the proteins responsible for your skin’s firmness and elasticity. When these peptides are applied to your skin, they essentially tell it to ramp up production, which naturally slows down as we age. This process helps to reduce the appearance of fine lines and wrinkles, leading to a plumper, more youthful look. They work beautifully alongside treatments like Corrective Microneedling™, which also stimulates collagen, creating a powerful combination for skin rejuvenation.

Neurotransmitter-Inhibiting Peptides

If you’re concerned about expression lines—those pesky wrinkles that form from smiling, frowning, or squinting—neurotransmitter-inhibiting peptides are what you need. These peptides work by gently relaxing facial muscles, softening the contractions that lead to dynamic wrinkles like crow’s feet and forehead lines. While not as dramatic as an injectable, they offer a non-invasive way to achieve a smoother appearance over time. Using a serum with these peptides can help maintain a relaxed and refreshed look, making them a fantastic addition to any anti-aging skincare routine.

Carrier Peptides

Think of carrier peptides as a dedicated delivery service for your skin. Their primary function is to transport essential trace elements, like copper and manganese, to skin cells. These minerals are vital for enzymatic processes involved in healing and collagen synthesis. By ensuring these key nutrients get where they need to go, carrier peptides support the skin’s natural repair and renewal functions. This makes them incredibly valuable for healing and maintaining overall skin health, especially when used in aftercare serums following a professional treatment.

Copper Peptides and Microneedling 

Always looking for ways to enhance our looks naturally, copper peptides have many additional benefits for the skin. Considerably, they are great in skin healing, especially after surgery. For instance, copper peptides are often recommended after non-invasive skin procedures such as laser resurfacing, dermabrasion, chemical peels, and microneedling procedures.

Copper peptides stimulate hair growth and improve skin conditions caused by acne, diabetes, and psoriasis. These naturally occurring complexes are also great for skin burns. Overall, copper peptides are an invaluable addition to your skin care regimen, improving the signs of aging by reducing inflammation and helping the skin build collagen.

Copper peptides and hyaluronic acid also promote the production of glycosaminoglycans which helps the skin tissue remain plump and supple.  That  is why copper peptide and hyaluronic acid are the active ingredients in MDPen Copper + HA mist.   This Copper + HA Mist helps in the healing process after an MDPen micro needling treatment. However, it is also recommended for daily use to heal and hydrate the skin.

Learn more about Copper + HA Mist, contact us today!

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The Science of Combining Microneedling and Peptides

Microneedling and peptides are a true power couple in skincare. On their own, they’re fantastic. But together, they create results that are truly remarkable. The treatment itself works by creating controlled micro-injuries in the skin, which prompts your body’s natural healing process and stimulates collagen and elastin production. This is where peptides come in. By applying them during this crucial healing window, you’re giving your skin the exact building blocks it needs to repair itself more efficiently and effectively. Think of it as providing premium fuel for your skin’s regeneration engine. This combination doesn’t just speed up recovery; it amplifies the skin-rejuvenating results of the entire treatment, leading to a smoother, firmer, and more radiant complexion.

How Microneedling Boosts Peptide Absorption

The magic of pairing these two lies in absorption. Normally, the skin’s outer layer, the stratum corneum, does a great job of keeping things out. While this is good for protection, it can limit how well your expensive serums work. Microneedling temporarily changes that. The procedure creates thousands of tiny, invisible channels in your skin. According to research from AHB Lab, these micro-channels act as direct pathways, allowing peptides to penetrate much deeper than they could on their own. This enhanced delivery means the peptides can get right to work in the deeper layers of the skin where collagen is produced, making them significantly more effective at hydrating, repairing, and rebuilding your skin from the inside out.

What the Research Says

The science supporting this combination is compelling, especially when it comes to specific types of peptides. Copper peptides, for instance, are well-studied for their role in skin health. They are known to support the processes that create collagen and repair damaged tissue. Research shows that using a copper peptide serum with microneedling can lead to noticeable improvements in skin texture, a reduction in fine lines, a more even skin tone, and better overall skin quality. This is why so many professionals incorporate high-quality aftercare serums containing these ingredients into their treatment protocols. They provide the essential components for a robust healing response and superior final results.

Insights from Skincare Professionals

Talk to any seasoned esthetician, and they’ll likely tell you about the difference they see when clients follow a proper post-microneedling routine. Professionals who integrate copper peptides into their Corrective Microneedling™ plans often report that their clients experience less downtime. The soothing and reparative properties of these peptides can help calm the skin more quickly after a procedure. This leads to a more comfortable healing process and, ultimately, greater client satisfaction. When clients see better, faster results with minimal discomfort, they are happier and more confident in the treatment’s effectiveness.

A Detailed Microneedling Aftercare Timeline

Understanding what to expect after your microneedling session can make the healing process feel much more manageable. Your skin goes through distinct phases of recovery, and knowing what’s happening at each stage helps you care for it properly. For the first day or two, your skin will likely look and feel like it has a mild sunburn. This is the initial inflammatory response, which is a critical part of the healing cascade. As the days progress, this redness will subside, and you’ll move into the proliferation phase, where the real rebuilding work begins. Following a timeline helps you use the right products at the right time and avoid anything that could hinder your beautiful results.

The First 1-4 Days: The Inflammatory Phase

Immediately following your treatment and for the next few days, your skin is in the inflammatory phase. During this time, your immune cells are called to the area to begin the healing process, and collagen production kicks off. It’s completely normal to experience some mild redness, swelling, and tightness. You might also notice some light flaking or peeling as your skin begins to turn over. The key during this phase is to be incredibly gentle. Use a mild cleanser, apply soothing serums recommended by your practitioner, and keep your skin hydrated. Avoid any harsh ingredients or activities that could cause further irritation.

Days 4-14: The Proliferation Phase

Once the initial redness has calmed down, your skin enters the proliferation phase. This is when your skin cells are actively working to form new tissue and build fresh collagen and elastin. Your complexion will start to look and feel more normal, but the healing is still happening beneath the surface. This is the perfect time to continue supporting your skin with nourishing ingredients. Products containing copper peptides are highly recommended during this stage to aid in the repair process. It’s also essential to be diligent with a broad-spectrum mineral sunscreen, as your new skin is especially vulnerable to sun damage.

After 14 Days: The Maturative Phase

After about two weeks, you enter the final stage of healing, known as the maturative or remodeling phase. During this period, the new collagen that was formed becomes stronger and more organized, leading to long-term improvements in your skin’s structure and appearance. You may start to see a noticeable difference in your skin’s texture, firmness, and overall glow. At this point, you can typically return to your regular skincare routine, but it’s always best to check with your practitioner first. Continuing to use products with peptides and antioxidants will help maintain and enhance your results over time.

How to Apply Serums After Microneedling

How you apply your skincare products after microneedling is just as important as which products you use. Your skin is in a uniquely receptive state, and proper application ensures you get the maximum benefit from your serums without causing irritation. The goal is to be gentle and deliberate. You want to deliver the active ingredients deep into the skin without rubbing or pulling, which could aggravate the sensitive tissue. Using clean hands and a light touch is non-negotiable. This careful approach will support the healing process and help you achieve that smooth, radiant complexion you’re looking for.

When to Apply Peptides for Best Results

Timing is everything. To take full advantage of the micro-channels created during your treatment, you should apply your peptide serum almost immediately after the session is complete, or as soon as your practitioner advises. This allows the peptides to travel deep into the skin while those pathways are most open. Applying a peptide-based moisturizer afterward can help seal in the serum and provide an additional layer of hydration and protection. Continuing to apply your peptide serum morning and night for the following weeks will continue to support the collagen-building process as your skin heals.

A Step-by-Step Application Guide

Applying your serum correctly will make a world of difference. First, ensure your hands are freshly washed. If you’re cleansing your face, use a very gentle, non-foaming cleanser and lukewarm water, then pat your skin dry with a clean towel. Dispense a few drops of your peptide serum onto your fingertips. Instead of rubbing it in, gently pat or press the serum onto your face, ensuring even coverage. This technique is less abrasive on sensitive skin. Allow the serum to absorb for a minute or two before following up with a simple, hydrating moisturizer and, if it’s daytime, a generous layer of mineral-based SPF 30 or higher.

Key Ingredients for Your Post-Treatment Routine

While peptides are the star of the show, a well-rounded post-microneedling routine includes a few other key ingredients to support healing and enhance your results. The focus should be on hydration, calming, and barrier repair. Your skin has just undergone an intensive workout, and now it needs gentle, nourishing care to recover properly. Think of your post-treatment products as a support team, each with a specific job to do. Hyaluronic acid provides a surge of moisture, niacinamide calms redness, and ceramides rebuild your skin’s protective barrier. Together, these ingredients create the ideal environment for your skin to heal beautifully.

Other Recommended Ingredients for Healing

To create a comprehensive aftercare plan, look for products that contain gentle, restorative ingredients. Hyaluronic acid is a superstar for hydration, as it can hold up to 1,000 times its weight in water, helping to plump and moisturize the skin from within. Niacinamide is another excellent choice for its anti-inflammatory properties, which can help reduce redness and strengthen the skin barrier. Finally, growth factors are powerful communicators that signal your cells to repair and regenerate. Including these ingredients alongside your peptides will give your skin everything it needs for a smooth and speedy recovery.

Niacinamide

Niacinamide, a form of vitamin B3, is a versatile ingredient that’s particularly beneficial for post-procedure skin. Its primary role here is to calm inflammation and reduce the redness that’s common after microneedling. It also works to strengthen your skin’s natural barrier, helping it retain moisture and protect itself from external irritants. By improving barrier function, niacinamide ensures your skin stays hydrated and resilient throughout the healing process. It’s a gentle yet effective ingredient that plays well with others, making it a perfect addition to your recovery routine.

Ceramides

Think of ceramides as the mortar that holds your skin cells together. They are lipids that are essential for a healthy skin barrier, preventing water loss and protecting your skin from the environment. After a microneedling treatment, your skin barrier is temporarily compromised, making it more susceptible to dryness and irritation. Applying a moisturizer rich in ceramides helps to replenish these crucial lipids, effectively rebuilding your skin’s protective wall. This not only keeps your skin soft and hydrated but also helps lock in the beneficial ingredients from your serums.

Growth Factors

Growth factors are naturally occurring proteins in our bodies that play a vital role in maintaining healthy skin structure. They act as messengers, instructing cells to grow, repair, and survive. When applied topically after microneedling, they can support your skin’s natural regeneration process. They help to accelerate healing and further stimulate the production of collagen and elastin. Incorporating a serum with growth factors can give your skin an extra edge, helping to improve firmness, texture, and overall skin quality as you recover.

Soothing Botanicals

Sometimes, the simplest ingredients can provide the most comfort. Soothing botanicals like aloe vera, chamomile, and green tea extract are excellent for calming post-microneedling skin. These ingredients are known for their anti-inflammatory and antioxidant properties, which can help reduce redness and irritation. They provide a gentle, cooling sensation that can feel incredibly relieving on sensitive skin. Look for these ingredients in your mists, serums, or light moisturizers to add an extra layer of comfort to your aftercare routine.

Critical Safety Warnings: What to Avoid After Microneedling

Knowing what *not* to do after microneedling is just as important as knowing what to do. Because your skin barrier is temporarily open, it’s more vulnerable to irritation, infection, and sun damage. Using the wrong products or engaging in certain activities can compromise your results and potentially harm your skin. For the first week, your mantra should be “simple and gentle.” This means stripping your routine back to the bare essentials: a mild cleanser, a healing serum, a basic moisturizer, and sunscreen. Avoiding potent active ingredients and environmental triggers will ensure your skin heals without complications.

Ingredients to Avoid for 5-7 Days

For at least the first week after your treatment, you’ll need to press pause on some of your usual skincare staples. Your skin is in a delicate state of repair, and potent active ingredients can do more harm than good, causing severe irritation and inflammation. According to guidance from skincare experts, it’s best to avoid retinoids, exfoliating acids, and alcohol-based products until your practitioner gives you the green light. Sticking to a minimal, gentle routine is the safest way to support your skin’s healing journey and protect your investment in the treatment.

Retinoids and Vitamin C

Retinoids (like retinol and tretinoin) and potent forms of Vitamin C (like L-ascorbic acid) are powerful ingredients that work by increasing cell turnover and providing antioxidant benefits. However, their potency is exactly why you should avoid them after microneedling. On freshly treated skin, they can be incredibly irritating, leading to excessive redness, peeling, and discomfort. It’s best to wait at least 5-7 days, or until your skin feels completely back to normal, before slowly reintroducing them into your routine.

Exfoliating Acids (AHAs and BHAs)

Exfoliating acids, such as glycolic acid (AHA) and salicylic acid (BHA), should also be avoided for at least a week. These ingredients work by dissolving the bonds between dead skin cells, but on skin with fresh micro-channels, they can cause significant stinging and inflammation. Your skin is already in a natural state of renewal from the microneedling itself, so adding chemical exfoliants is unnecessary and can disrupt the delicate healing process. Let your skin recover fully before you consider exfoliating again.

Alcohol, Fragrances, and Essential Oils

Check the ingredient lists on your products for potential irritants like denatured alcohol, synthetic fragrances, and essential oils. Alcohol-based toners and serums can be extremely drying and stinging on compromised skin. Similarly, fragrances and many essential oils are common allergens that can trigger inflammatory reactions, especially when the skin barrier is vulnerable. Opt for products that are specifically labeled as “fragrance-free” and formulated for sensitive skin to minimize the risk of a negative reaction.

Lifestyle and Other Precautions

Your daily habits also play a significant role in your recovery. For the first few days, it’s wise to treat your skin like a recovering patient that needs a calm, clean, and protected environment. This means making a few temporary adjustments to your routine, like skipping a sweaty workout or wearing a wide-brimmed hat when you go outside. These small precautions can make a big difference in preventing complications like infection or hyperpigmentation, ensuring you get the best possible outcome from your treatment.

Prioritize Sun Protection

Sun protection is non-negotiable after microneedling. Your skin is highly susceptible to UV damage, which can lead to hyperpigmentation and undo the benefits of your treatment. For the first 24 hours, it’s best to avoid direct sun exposure entirely. After that, apply a broad-spectrum, mineral-based sunscreen with an SPF of 30 or higher every single day, even if you’re indoors. Mineral sunscreens containing zinc oxide or titanium dioxide are generally better tolerated by sensitive, post-procedure skin than their chemical counterparts.

Avoid Heat and Sweat

For the first 48-72 hours, steer clear of activities that generate heat and sweat. This includes strenuous exercise, saunas, steam rooms, and even very hot showers. Heat can increase inflammation and redness, while sweat can introduce bacteria into the open micro-channels, increasing the risk of infection or breakouts. Keeping your skin cool and dry will help the initial healing phase go smoothly and comfortably.

Keep Your Routine Clean

Maintaining a clean environment for your skin is crucial. Always wash your hands thoroughly before touching your face or applying products. It’s also a great idea to sleep on a clean pillowcase the night of your treatment and use clean towels to pat your face dry. These simple hygiene practices help prevent bacteria from coming into contact with your healing skin, minimizing the risk of infection and ensuring a clear path to a beautiful result.

Frequently Asked Questions

Why are copper peptides so highly recommended after microneedling? Think of copper peptides as the ultimate support crew for your skin’s recovery. After a microneedling treatment, your skin is in a powerful rebuilding mode. Copper peptides are fantastic because they excel at calming inflammation and are essential for the processes that build new, healthy collagen. By applying them to your receptive skin, you’re providing the key materials needed for a faster, more efficient healing process, which leads to better and more visible results.

Can I just use my regular daily moisturizer instead of a special aftercare serum? While your daily moisturizer is great for maintaining your skin, it likely isn’t formulated for skin that’s actively healing. After microneedling, your skin barrier is temporarily open and needs specific, gentle ingredients that support repair without causing irritation. Aftercare serums are designed with this in mind, featuring high concentrations of healing ingredients like peptides, hyaluronic acid, and growth factors, while leaving out potential irritants like fragrances or heavy oils that could clog the micro-channels.

My skin feels tight and is flaking a bit after my treatment. Is this normal even if I’m using the right products? Yes, this is completely normal and actually a good sign! A feeling of tightness and some light flaking a few days after your procedure means your skin is going through its natural renewal process. The treatment has stimulated cell turnover, and your skin is shedding old cells to make way for the new, healthy tissue underneath. As long as you continue to be gentle and keep your skin well-hydrated with the recommended serums, you’re on the right track.

How soon can I go back to my normal skincare routine with actives like retinol and vitamin C? It’s best to give your skin a solid week to heal before reintroducing potent active ingredients. Your skin is working hard to repair itself, and using strong products like retinoids or exfoliating acids too soon can cause significant irritation and disrupt the recovery process. After about 5-7 days, or once your skin feels completely back to normal with no redness or sensitivity, you can slowly begin to add them back into your routine.

When is it safe to start wearing makeup again? You should wait at least 24 hours before applying any makeup to your skin. Your skin’s micro-channels need time to close to prevent bacteria from getting in and causing breakouts or infection. When you do start wearing makeup again, try to use a mineral-based formula for the first few days. It’s generally less irritating and less likely to clog pores on your sensitive, healing skin.

Key Takeaways

  • Microneedling Amplifies Product Absorption: The treatment creates micro-channels that act as direct pathways into the skin. This allows ingredients like peptides to penetrate far deeper than usual, making them more effective at stimulating repair and collagen production.
  • Focus on a Simple, Healing Routine: For the first week post-treatment, your goal is to hydrate and soothe. Use gentle cleansers and apply serums containing peptides and hyaluronic acid with a light patting motion, followed by a daily mineral sunscreen to protect your results.
  • Know Which Ingredients to Temporarily Avoid: Protect your investment by pausing potent actives for at least a week. Steer clear of retinoids, exfoliating acids (AHAs/BHAs), and strong vitamin C serums, as they can cause irritation and disrupt the healing process.

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