Corrective Microneedling™ is more than a cosmetic procedure; it’s a biologically intelligent treatment that maximizes the body’s natural healing mechanisms to drive transformation from the inside out. This clinical overview breaks down the microneedling process, providing technical insight for practitioners who want to elevate their clinical results and deliver optimal outcomes.

Creation of Microchannels

The procedure begins with the creation of microchannels—controlled micro-injuries made to the skin by applying the microneedling device. The MDPen Ultra device can deliver between 217,000 and 324,000 microchannels per minute, depending on needle configuration and technique. These micro-injuries act to trigger the body’s 3-phased healing/repair response.

Key Effects:

  • Mechanical stimulation of keratinocytes
  • Initial skin barrier disruption
  • Prepares skin for transdermal delivery of actives (e.g., HA, PRP, PDRN) applied during the treatment

Phase 1: Inflammatory Response (0-48 hours)

Immediately after the microchannels are created, the body initiates an inflammatory response. This involves platelet activation and the release of growth factors such as PDGF, TGF-β, VEGF, and EGF. 

Collagen Impact:

  • The high number of microchannels leads to greater release of pro-collagen signaling molecules.
  • Sets the stage for stronger fibroblast activity and more profound tissue regeneration.

This is where we see the flushing and pinpoint bleeding that practitioners monitor visually—it’s a signal that healing has begun.

Phase 2: Proliferation (2 – 7 days)

Fibroblasts and keratinocytes multiply rapidly to form a new extracellular matrix (ECM). Collagen I and III, elastin, and hyaluronic acid are actively synthesized. Due to the high number of microchannels created by the MDPen Ultra it can be concluded that the collagen production will be higher than during traditional microneedling.

Collagen Impact:

  • Greater microchannel density leads to higher fibroblast recruitment and more abundant early collagen (type III).
  • Improved vascularization helps support long-term collagen remodeling.

Practitioner Insight: Uniformity in device speed, overlap, and pressure contributes directly to the quality of ECM rebuilding.

Collagen and Elastin Proliferation Phase

Phase 3: Remodeling (1 week – 6 months)

New collagen fibers realign along natural tension lines, forming a more structured and elastic dermis. Collagen III is reorganized into stronger Collagen I.  Skin structure tightens, scars smooth out, and pigmentation evens out. Epidermal barrier fully restores, and dermal architecture strengthens over time.

Collagen Impact:

  • Enhanced collagen turnover due to a larger treatment area and longer-lasting fibroblast activity.
  • Results in thicker, firmer, more resilient skin compared to traditional microneedling.
  • Cumulative treatments compound this effect, often delivering visible improvements in fewer sessions.

This is where the transformation becomes visible—lasting changes in the skin’s architecture occur during this phase.

 

Advanced Corrective Outcomes

Acne Scars before and after

Corrective Microneedling™ enhances each biological phase through speed, precision, and depth control.

Unique Corrective Factors:

  • Higher vascular density via enhanced angiogenesis
  • More efficient absorption during treatment (up to 92%) of topical actives due to open microchannels
  • Greater growth factor saturation in the treatment zone

Key Devices & Variables:

  • Motor torque, RPM (revolutions per minute), and needle count affect output
  • Technique matters: Depth varies: 0.1–0.25mm peri-orbital, 0.5–1.5mm for cheeks/forehead


Practitioner Takeaways

  • Visual observation is critical. Look for subtle flushing or pinpoint bleeding as depth guides.
  • Patient communication improves comfort and safety. Use a 1–10 pain scale to adjust intensity.
  • Technique matters: Hold skin taut, maintain steady hand speed, 10% overlapping 1-inch strokes, 3-pass crosshatch pattern recommended, and avoid overtreatment.

Corrective Microneedling™ is both an art and a science. Knowing how to create ideal conditions for skin remodeling makes all the difference.

 

A Word on Device Technology

Not all devices are created equal. Precision delivery of microchannels matters. Devices that allow modulation of torque and needle stroke produce more uniform results.

Example: The MDPen device reduces RPM to deliver more deliberate micro-injuries—up to 324,000 per minute—while minimizing unnecessary trauma. Future iterations may increase needle count for added performance.

The Patient Variable

As a practitioner, you can control your technique and device—but not the patient once they leave your practice. How your patients care for their newly treated skin will directly impact their result.  Educate them on:

  • Using only recommended post-care products
  • Maintaining skin hydration and barrier support
  • Avoiding makeup, actives, or sun exposure for 48–72 hours
  • Proper use of sun protection throughout their treatment protocol

Conclusion

Corrective Microneedling™ is a next-level modality that combines device technology, practitioner skill, and biological intelligence. When done correctly, it initiates a full skin transformation that is visibly measurable and biologically validated.

Schedule an appointment to see a demonstration of the MDPen Ultra.